The distance from Athens to the island of Lefkada, is around 380km through the bridge of Rio- Antirrio (Patra) and the new Ionian highway. The distance from Thessaloniki to Lefkada island is around 377km.
Frequent flights are performed from Athens International Airport (Eleftherios Venizelos) to the Aktion airport, 17km from Lefkada, next to the town of Preveza. Consult your air carrier as there are more flights available during summer months.
There is no direct line to travel to Lefkada by ship. Travelers can use the port of Igoumenitsa and continue driving for about 95 km. Alternatively, the port of Patra can be used and then drive for about 180km. There are daily timetables connecting the Corfu island and Igoumenitsa with many ports of Italy. You can find timetables here.
Bus is another way to get to Lefkada island, from Athens is around 5 hours and from Thessaloniki is around 4, 5 hours.